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PerioAid® Bioadhesive Gel: a gel formulated with evidence-based concentrations

News

10 Mar 2020

The concentration levels of chlorhexidine, hyaluronic acid and panthenol present in Perio·Aid® Bioadhesive gel are backed by numerous scientific articles and are ideal for obtaining an optimum effect of the product’s properties. 

Perio·Aid® Bioadhesive gel is an oral gel with antiseptic properties that heals and regenerates oral tissues, indicated after periodontal and/or peri-implant treatment, surgery and other therapies, and which favours recovery of the oral mucosa thanks to its bioadhesive property. 

The gel contains the antiseptic active ingredient chlorhexidine (0.2%), with antibacterial and antiplaque properties, limiting biofilm and reducing the risk of bacterial infections, as well as diminishing inflammation of the gums and mucosa. The ideal concentration of chlorhexidine in bioadhesive gels is 0.2%, as shown in the literature consulted. 

The gel also contains 0.2% high-molecular-weight hyaluronic acid in its formulation, which helps to repair and regenerate damaged oral tissues and promotes healing. Most scientific papers in the literature support the efficacy of 0.2% hyaluronic acid. It has been shown that hyaluronic acid at said concentration works by promoting the regeneration of damaged tissues, aiding in their repair. Higher concentrations do not ensure any greater effect since its main action, that of shielding for the wound, is already performed at a concentration of 0.2%. 

Another feature differentiating Perio·Aid® Bioadhesive gel from others is its inclusion of 5% panthenol, or provitamin B5, which reduces gingival inflammation and stimulates tissue regeneration, aiding also in its recovery. It also has moisturising and soothing properties. There are likewise numerous articles in the literature that support the use of this active substance and at the above-mentioned concentration. 

The other excipients in the formulation, including the mucoadhesive polymer hydroxyethylcellulose, also contribute to the bioadhesive effect that provides a protective layer for the gums and mucosa. This layer helps prevent the formation of biofilm, prolonging the antiseptic effect of the chlorhexidine by slowly releasing it over the lesion. 

Bibliography

  1. Teshome A. The efficacy of chlorhexidine gel in the prevention of alveolar osteitis after mandibular third molar extraction: a systematic review and meta-analysis. BMC Oral Health 2017 May; 17 (1): 82. 
  2. Zhou J, Hu B, Liu Y, Yang Z, Song J. The efficacy of intra-alveolar 0.2% chlorhexidine gel on alveolar osteitis: a meta-analysis. Oral Dis 2017 Jul; 23 (5): 598-608. 
  3. Yıldırım S, Özener HÖ, Doğan B, Kuru B. Effect of topically-applied hyaluronic-acid on pain and palatal epithelial wound healing: An examiner-blind, randomized, controlled clinical trial. J Periodontol 2017 Sept; 89 (1): 1-14. 
  4. Koray M, Ofluoglu D, Onal EA, y cols. Efficacy of hyaluronic acid spray on swelling, pain, and trismus after surgical extraction of impacted mandibular third molars. Int J Oral Maxillofac Surg 2014; 43: 1.399-1.403. 
  5. Nolan A, Baillie C, Badminton J, y cols. The efficacy of topical hyaluronic acid in the management of recurrent aph-thous ulceration. J Oral Pathol Med 2006; 35: 461-465. 
  6. Lee JH, Jung JY, Bang D. The efficacy of topical 0.2% hyaluronic acid gel on recurrent oral ulcers: Comparison be-tween recurrent aphthous ulcers and the oral ulcers of Behcet’s disease. J Eur Acad Dermatol Venereol 2008; 22: 590-595. 
  7. Ebner F, Heller A, Rippke F, Tausch I. Topical use of dexpanthenol in skin disorders. Am J Clin Dermatol 2002; 3 (6): 427-433. 
  8. Heise R, Skazik C, Marquardt Y, y cols. Dexpanthenol modulates gene expression in skin wound healing in vivo. Skin Pharmacol Physiol 2012; 25 (5): 241-248. 
  9. Proksch E, de Bony R, Trapp S, Boudon S. Topical use of dexpanthenol: a 70th anniversary article. J Dermatol Treat 2017 Dec; 28 (8): 766-773. 

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