The mouth is one of the main routes of entry for SARS-CoV-2 (the coronavirus responsible for the COVID-19 pandemic). This virus is transmitted mainly through droplets of saliva that are expelled when an infected person speaks , coughs, sneezes, etc.
Various studies have shown that a large number of specific receptors to which SARS-CoV-2 binds are found in the oral cavity (Xu et al. 2020), numbers larger even than in the lungs. Not only that, but during the first 10 days of infection, when the patient may be asymptomatic and highly contagious, SARS-CoV-2 mainly infects the upper respiratory tract: nose, throat and mouth (Wölfel et al. 2020).
Therefore, the mouth can be considered both a route of entry for viruses into the body, an area where viruses can multiply and a route of transmission of the virus to other people.
CPC (cetylpyridinium chloride) is a safe and effective antiseptic, which has been shown to effectively reduce certain bacteria, fungi and viruses. It is widely used in toothpastes and mouthwashes for the prevention of oral diseases
Specifically, it has shown to be efffective against viruses such as influenza, rotavirus, herpes simplex virus, hepatitis B and some coronaviruses (Popkin et al. 2017; Mukherjee et al. 2017; Shen et al. 2019; Álvarez et al. 2020; Seo et al. 2019), including coronavirus strains that are used to evaluate potential efficacy against SARS-CoV-2 (Green et al. 2020; Meyers et al. 2020). Studies recently completed by the IRSI Caixa group (Barcelona) have confirmed the ability of CPC to be active against SARS-CoV-2.
Because it could help decrease the amount of SARS-CoV-2 virus in the mouth. Having less virus in the oral cavity and in saliva would reduce the risk of a coronavirus-infected person transmitting it to a healthy person. It could also help develop a less severe form of COVID-19 (Herrera et al. 2020).
The membrane of this coronavirus is a fundamental element in the process of infecting human cells. CPC is capable of destabilising this viral membrane, thus preventing it from infecting human cells. In other words, CPC may help reduce the infectivity of SARS-CoV-2.
If the virus is already in your mouth, it is a sign that you have the infection. However, although there is still no clinical evidence of this, the lesser the amount of virus in saliva, the lower the risk that the virus can be transmitted through saliva when talking, coughing, sneezing, etc.
Some studies have shown that there is a direct relationship between the amount of virus and the severity of COVID-19 (Liu et al. 2020). That is, the greater the viral load, the greater the risk that COVID-19 will be severe. Considering that in the initial days, the virus is located in the oral cavity and in the throat (Wolfel et al. 2020) and that it then enters into the body (to the lungs), reducing the virus in the mouth could help there to be less risk of a severe form of COVID-19. However, other risk factors have an influence such as, mainly, the immune system of each person and not having other pathologies such as hypertension, heart disease, diabetes or obesity.
No, CPC does not cure COVID-19 disease, nor does it prevent contagion. CPC may help reduce viral load and prevent transmission from a carrier of the virus. It is one more preventive measure, to be added to the other measures including social distancing, hand washing with soap and water or hydroalcoholic gels, the use of masks, etc.
Mouthwashes with CPC can play a fundamental role during this period for different reasons:
There are no studies restricting the age of CPC use. The main limitation of use with regard to age is provided for mouthwashes, which are recommended as of age 6, when children are believed to have mastered the swallowing reflex. As for toothpastes, it is important to consider that age limitation is usually established if fluoride is included (age-specific) rather than due to the use of CPC and in the case of products with Chlorhexidine + CPC from the age of 12 for the use of CHX.
There are no studies restricting the age of CPC use. The main limitation of use with regard to age is provided for mouthwashes, which are recommended as of age 6, when children are believed to have mastered the swallowing reflex. As for toothpastes, it is important to consider that age limitation is usually established if fluoride (age-specific) or Chlorhexidine are included rather than due to the use of CPC.
VITIS CPC protect toothpaste CPC 0.14%
VITIS CPC protect mouthwash CPC 0.07%
VITIS CPC protect Spray CPC 0.07%
VITIS gingival toothpaste CPC 0.05%
VITIS gingival mouthwash CPC 0.05%
VITIS orthodontic toothpaste CPC 0.05%
VITIS orthodontic mouthwash CPC 0.05%
VITIS electric toothpaste CPC 0.05%
VITIS aloe vera mouthwash CPC 0.02%
PERIO·AID 0.12% treatment/Intensive Care mouthwash CHX 0,12% + CPC 0,05%
PERIO·AID 0.12% treatment/Intensive Care Spray CHX 0,12% + CPC 0,05%
PERIO·AID 0.05% maintenance and control/Active control mouthwash CHX 0,12% + CPC 0,05%
HALITA toothpaste CPC 0.05%
HALITA mouthwash CPC 0.05%
HALITA Spray CPC 0.05%
HALITA Spray forte CPC 0.05%
INTERPROX Gel CPC 0.30%
PHB gingival toothpaste CPC 0.05%
PHB gingival mouthwash CPC 0.05%
PHB total toothpaste CPC 0.05%
PHB total mouthwash CPC 0.02%
PHB total plus mouthwash CPC 0.05%
PHB fresh mouthwash CPC 0.02%
Multiple international organisations [recommend] rinsing with antiseptic mouthwashes, such as CPC, before a patient undergoes an operation in the dental clinic:
National - Health Authority
Germany - Federal Dental Association
Australia - Australian Dental Association
Belgium - Conseil de l’art dentaire de Belgique
Canada - Canadian Dental Association
Chile - Dental Association of Chile
Colombia - Minsalud / Ministry of Health
Spain - General Dental Council of Spain
United - States American Dental Association (ADA)
France - Association dentaire française (ADF)
Netherlands - Nederland Commissie Leidraad Mondzorg Corona
Italy - Associazione Nazionale Dentisti Italiani (ANDI)
Malta - Superintendent of Public Health
Morocco - CCTD - CHU Ibn ROCHD - Casablanca
Norway - Norwegian Institute of Public Health
Netherlands - Royal Dutch Dental Association / Commissie Leidraad Mondzorg Corona
Peru - Dental Association of Peru
Portugal - Ordem médicos dentistas
Switzerland - Swiss Dental Association (SSO)
In addition to being used in the dental clinic, they could be extremely useful for longer-term daily use during the pandemic, to prevent transmission by both symptomatic carriers of the virus and by those who are unaware they have it.
VITIS CPC protect spray can be used anytime, anywhere (for example, before an event), to sustain CPC protection for longer periods. Plus, it can reach areas that are difficult to access, such as the back of the mouth.
Yes, they can use them, under the supervision of a dentist. Pregnant women are at a higher risk for gum disease due to the accumulation of bacterial plaque, and this risk is increased by the physiological changes that occur during pregnancy. CPC is considered safe and effective at authorised concentrations, and has shown to improve periodontal and bacterial plaque indices in pregnant women (Jeffcoat et al. 2011; Geisinger et al. 2013; Jiang et al. 2016).
In addition, there is evidence linking periodontitis (the most serious gum disease) with adverse pregnancy outcomes, such as an increased risk of preterm delivery and low birth weight. In fact, studies have been conducted on pregnant women with periodontitis, evaluating whether the use of CPC helped to improve periodontal condition and thereby reduce the risk of adverse pregnancy outcomes (Jeffcoat et al. 2011; Jiang et al. 2016). For this reason, gum care during pregnancy is considered even more important, with measures such as brushing, daily interproximal hygiene and the use of toothpastes and mouthwashes containing CPC.
The content shown below corresponds to Spain and to products sold under country-specific registration.OK