News for dentistry professionals
16 Nov 2016
Jose Bagán Sebastián
Prevalence varies depending on the geographical area analysed, being higher in Asian countries (up to 25%-30% of all tumours), while in the United States or Europe it is only 2%-4%. The incidence in Spain is between 5.7 and 12.9 cases per 100,000 men/year and 0.6 to 2.1 cases per 100,000 women/year, with an estimated 5,000 new oral cancer patients in Spain in 2016, causing 1,200 deaths(2).
By and large, oral cancer has in the past been predominantly male; however, due to the increasing numbers of female smokers, this ratio has gradually been declining. There has also been an increase in occurrence among younger women not directly related to smoking. As far as age goes, despite being a tumour whose onset is, on average, most prevalent in those aged 50 years and over, in recent years the number of cases in patients of 40 years and under has increased(3).
Although the aetiology of oral cancer remains unknown, there are a number of carcinogenic risk factors favouring the appearance of mutations in the DNA of keratinocytes and leading to oral cancer.
The two main risk factors involved in the origin of these mutations are smoking and drinking, so that the synergy between the two results in an increased risk of up to 13 times that of non-drinkers and non-smokers(4).
Similarly, diet is considered a factor influencing the disease, with an antioxidant-rich diet having a beneficial effect. The prior existence of lesions may also be involved in the aetiopathogenesis of oral cancer. Such lesions are characterised by structural alterations of the mucosal epithelium with a considerable tendency to malignancy, and are considered potentially malignant oral disorders. Of these, leukoplakia and erythroplakia stand out due to their frequency and rate of malignant transformation.
The survival rate for oral cancer after five years is 50%-60%, with no significant increase in recent years despite the considerable progress and improvement in the various therapeutic techniques. These low survival rates are due to the delay in the detection of cancerous lesions, leading to the diagnosis in 60% of the cases at an advanced stage. Therefore, early diagnosis at initial stages currently remains the primary objective in the treatment of these patients(5).
The role of the dentist in the prevention of oral cancer is of great importance, in education, early detection, diagnosis and management of patients with oral cancer.
It is estimated that up to 80% of new cases of oral cancer could be avoided if smoking were eliminated and drinking reduced, thus decreasing the risk by up to 35% 1-4 years after having quit smoking and 80% after 20 years. A proper diet including fruits and vegetables has also been associated with a significant decrease in the risk of developing oral cancer.
Dentists should thus encourage their patients to adopt a healthy diet and cut out the consumption of toxins(3).
The prognosis and the survival rate change radically with early diagnosis, since early stages (stages I and II: those in which there are no cervical metastases and the size of the lesion is less than four centimetres) show a high survival rate of up to 75% after five years, while in advanced stages (stages III and IV with lesions larger than four centimetres and/or cervical lymphadenopathy or distant metastases) the prognosis worsens dramatically, with an average survival rate of 20%-30% after five years.
Systematic examination of the oral mucosa should therefore be part of all routine dental examinations, identifying any suspected incipient malignant lesions(5)(6):
Oral health specialists also play an important role at this stage, since patients diagnosed and treated for oral cancer will require monitoring to prevent recurrence or the onset of new primary tumours, as well as procedures to reduce treatment-related morbidity: treatment of mucositis, prevention of tooth decay, tooth extractions prior to radiation therapy, oral rehabilitation, etc.
Early diagnosis remains an essential task for dentists in the management of patients with oral cancer, as it significantly increases their chances of recovery, helps avoid the need for radical treatment and improves patients’ quality of life.
(1) Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JWW, Comber H, Forman D, Bray F. Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012. Eur J Cancer 2013; 49 (6): 1.374-1.403.
(2) El desafío de las enfermedades bucodentales – Una llamada a la acción global. Atlas de Salud Bucodental. 2ª ed. Ginebra: Federación Dental Internacional (FDI); 2015.
(3) Warnakulasuriya S. Living with oral cancer: epidemiology with particular reference to prevalence and life-style changes that influence survival. Oral Oncol 2010; 46 (6): 407-410.
(4) Hashibe M, Brennan P, Chuang SC, Boccia S, Castellsague X, Chen C, y cols. Interaction between tobacco and alcohol use and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. Cancer Epidemiol Biomarkers Prev 2009; 18 (2): 541-550.
(5) Bagan JV. Medicina y patología bucal. Valencia: Medicina Oral SL; 2013.
(6) Scully C, Sciubba JJ, Bagan JV. Oral mucosal precancer and cancer: A helpful discriminating clinical tool. Med Oral Patol Oral Cir Bucal 2015; 20 (5): e587-590.
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