DENTAID Research Center is one of the leading reference centres for oral health research. Its multidisciplinary approach is aimed at the generation of scientific knowledge and the development of solutions for the care and improvement of human oral health. 

DENTAID Research Center is organised into different areas; one of these is the Oral Microbiology Laboratory, a place where scientists work on specialised research projects with regard to the main infectious diseases of the mouth. In addition, they develop analysis and control techniques to test and certify the quality and effectiveness of DENTAID products. 

To carry out this innovative research, DENTAID Research Center possesses state-of-the-art equipment, including the artificial mouth, confocal laser scanning microscopy and its latest acquisition, a next generation MiSeq sequencer. 

The latest generation of sequencing techniques, massive parallel sequencing, or “next-generation sequencing”, have totally changed the way research is done, revolutionising our understanding of biological systems. 

In this new era, it is possible to identify all the microbiota that inhabits a specific ecosystem, and also to ascertain the role of each of these microorganisms within their habitat. Thanks to these technologies, we now know more about the great diversity of microorganisms that inhabit the human body and that evolve together with us. 

It has made it possible to determine that the microbiota of the oral cavity is extremely diverse and is very different from the intestinal microbiota or that which inhabits other regions of the body. However, there are still many challenges ahead: determining how microbiota differ in different human populations; determining what the changes in microorganisms are that lead to dysbiotic microbiota; understanding how commensal microorganisms interact with pathogens; and of course, how these bacterial cells interact with their human hosts. 

DENTAID has taken up the gauntlet, and with the acquisition of the Illumina MiSeq sequencer, is working to help answer all these questions, to provide insight and develop new strategies and tools to improve and maintain people’s oral health. 

WHAT DOES THE MISEQ NEW GENERATION SEQUENCER PROVIDE US WITH? 

The MiSeq sequencer allows us to study the composition of the oral microbiota, as well as the gene expression of microorganisms at different stages and conditions of the development of the oral biofilm, in addition to allowing the sequencing of the microorganisms’ genome. 

DENTAID Research Center, a place where science, experience and knowledge merge into one primary focus, to offer pioneering products and solutions with guaranteed effectiveness and to continue working for the care and improvement of people’s oral health.